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Our reagents for the synthesis of DNA and RNA oligonucleotides are produced and packaged to ensure the highest performance on commercial synthesizers.

Our universal supports and synthesis supplies are produced and packaged to ensure the highest performance on commercial oligonucleotide synthesizers.

Glen Research ancillary reagents are produced and packaged to ensure the highest performance on commercial oligonucleotide synthesizers.

Our products for oligonucleotide modification and labeling are produced and packaged to ensure the highest performance on commercial synthesizers.

Since the DMT group binds strongly to reverse phase supports, the full-length sequences can be retained in a cartridge while the failure sequences are eluted.

Glen Report Newsletter

Glen Report Volume 32.1 is now available.

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Featured Article

2'-MOE RNA Phosphoramidites

Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA.

Explore Oligonucleotide Applications

Glen Research offers a wide range of products for oligonucleotide applications.

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Design of Fluorescent Probes

Glen Research offers a wide selection of fluorophores and fluorescence quenchers, which can be added during oligonucleotide synthesis at the 5′- or 3’-terminus or within the sequence. The resultant fluorescent oligonucleotide probes are typically used in a wide variety of applications like genetic and genome analyses, and forensic analysis. Common applications of fluorescent oligonucleotide probes are FRET and Molecular Beacon probes.

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