Introducing Serinol Nucleic Acids (SNA): an acyclic phosphodiester backbone derived from serinol, offering enhanced stability and diverse applications in RNA interference, molecular beacons, splice switching, and more.
Suitable for a wide range of applications including agarose and polyacrylamide gel electrophoresis, plasmid characterization, DNA sequencing gels, and more, offering versatility in nucleic acid analysis.
The latest products in our Black Hole Quencher™ (BHQ) offerings have the same innovative design, with an added O-DMT group, allowing for easy modification internally or at the 3′-end of oligonucleotides using universal supports.
Gene editing through the blood-brain barrier using ultrasound
Microbubble enhanced focused ultrasound methods are making it possible via systemic administration to deliver drugs to specific deep brain structures. Download the note to learn more.
Since the DMT group binds strongly to reverse phase supports, the full-length sequences can be retained in a cartridge while the failure sequences are eluted.
Serinol nucleic acid (SNA) is an acyclic phosphodiester backbone based on serinol (2-amino-1,3-propanediol). It shares the same three carbon skeleton as ribose and has nucleobases that are one atom further away from the skeleton than standard nucleic acids. SNA hybridizes to both DNA and RNA. Read more!
Explore Oligonucleotide Applications
Glen Research offers a wide range of products for oligonucleotide applications.
Glen Research offers a wide selection of fluorophores and fluorescence quenchers, which can be added during oligonucleotide synthesis at the 5′- or 3’-terminus or within the sequence. The resultant fluorescent oligonucleotide probes are typically used in a wide variety of applications like genetic and genome analyses, and forensic analysis. Common applications of fluorescent oligonucleotide probes are FRET and Molecular Beacon probes.