The challenge for first generation universal supports was that complete dephosphorylation using ammonium hydroxide, AMA or anhydrous methylamine gas takes longer than most companies wish to allocate. A more recent development has been the use of a support based on a molecule which is "conformationally preorganized" to accelerate the dephosphorylation reaction. By using a rigid bicyclic molecule on the support, the rate of elimination is markedly faster than earlier universal supports. We are happy to offer Glen UnySupport in a variety of popular formats under license from Ionis Pharmaceuticals
This product is covered by US Patent 7,202,264 owned by Ionis Pharmaceuticals, Inc..