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Glen UnySupport

The challenge for first generation universal supports was that complete dephosphorylation using ammonium hydroxide, AMA or anhydrous methylamine gas takes longer than most companies wish to allocate. A more recent development has been the use of a support based on a molecule which is "conformationally preorganized" to accelerate the dephosphorylation reaction. By using a rigid bicyclic molecule on the support, the rate of elimination is markedly faster than earlier universal supports. We are happy to offer Glen UnySupport in a variety of popular formats under license from Ionis Pharmaceuticals.

The extended time required to cleave the succinate linkage of the original Glen UnySupport can be problematical, especially in high-throughput production of oligos, due to the outgassing of ammonia and/or methylamine. Using a diglycolate linkage in Glen UnySupport FC instead of the succinate in Glen UnySupport, a significant increase in the rate of cleavage has been achieved. With the cleavage time of Glen UnySupport FC reduced to less than 5 minutes with AMA, there is minimal loss of volatile gas. We offer Glen UnySupport FC attached to 1000Å CPG in a variety of formats suited to high throughput synthesis, as well as in bulk for more routine use.


INTELLECTUAL PROPERTY

This product is covered by US Patent 7,202,264 owned by Ionis Pharmaceuticals, Inc.. 

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