Glen UnySupport™ is a universal support based on a conformationally preorganized molecule to accelerate the dephosphorylation reaction. The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligonucleotide synthesis. Glen UnySupport™ is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection. Higher angstrom universal supports are ideal for long syntheses (>150 mer) and can be utilized with modifier phosphoramidites for which 2000Å supports are not readily available.
|Storage||Controlled room temperature or lower, dry|
REFERENCE(S)| 1 A.P. Guzaev, and M. Manoharan, J Am Chem Soc, 2003, 125, 2380- 2381.| 2 R.K. Kumar, A.P. Guzaev, C. Rentel, and V.T. Ravikumar, Tetrahedron, 2006, 62, 4528.