Oligonucleotide structural analysis has demonstrated that DNA and RNA nucleic acid sequences containing G-tracts separated by other bases spontaneously fold into G-quadruplex structures. G-quadruplexes are formed when four adjacent guanine residues stack in a cyclic Hoogsteen hydrogen-bonding arrangement leading to four-stranded helical structures. The study of G-quadruplexes in basic genetic processes is an active area of research in telomere, gene regulation, and functional genomics research. Guanine analogues that have different hydrogen bonding characteristics - 7-deaza-8-aza-dG and 7-deaza-dG - have proved useful in analyzing G-quadruplex structures. Similarly, common DNA lesions - 8-oxo-dG and abasic sites - have been used to investigate their effect on G-quadruplex structure and activity.

5 Product Results
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  • 8-Amino-dG-CE Phosphoramidite
    8-Amino-dG-CE Phosphoramidite (10-1079)
    Catalog #: 10-1079  |  CAS #: 166092-91-7
    Formal Name: 5'-Dimethoxytrityl-N2,N8-bis(dimethylaminomethylidine)-8-amino-2'-deoxyGuanosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 7-Deaza-8-aza-dG-CE Phosphoramidite (PPG)
    7-Deaza-8-aza-dG-CE Phosphoramidite (PPG) (10-1073)
    Catalog #: 10-1073
    Formal Name: 5'-Dimethoxytrityl-N-dimethylformamidine-8-aza-7-deaza-2'-deoxyGuanosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 8-oxo-dG-CE Phosphoramidite
    8-oxo-dG-CE Phosphoramidite (10-1028)
    Catalog #: 10-1028  |  CAS #: 143060-53-1
    Formal Name: 5'-Dimethoxytrityl-N2-isobutyryl-8-oxo-deoxyGuanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 8-Br-dG-CE Phosphoramidite
    8-Br-dG-CE Phosphoramidite (10-1027)
    Catalog #: 10-1027  |  CAS #: 198080-37-4
    Formal Name: 5'-Dimethoxytrityl-N2-dimethylaminomethylidene-8-bromo-2'-deoxyGuanosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 7-deaza-dG-CE Phosphoramidite
    7-deaza-dG-CE Phosphoramidite (10-1021)
    Catalog #: 10-1021  |  CAS #: 121767-97-3
    Formal Name:


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