Cholesterol Labeling

Potential therapeutic oligonucleotides must permeate the cell membrane for optimal activity.  The addition of lipophilic groups to an oligonucleotide would be expected to enhance cellular uptake/membrane permeation.  The use of cholesteryl oligos and the consequent improvement in activity has been described.  We have designed our Cholesteryl products with triethyleneglycol (TEG) spacers for maximum solubility.

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  • Cholesteryl-TEG Phosphoramidite
    Cholesteryl-TEG Phosphoramidite (10-1975)
    Catalog #: 10-1975  |  CAS #: 873435-29-1
    Formal Name:


  • 5'-Cholesteryl-TEG Phosphoramidite
    5'-Cholesteryl-TEG Phosphoramidite (10-1976)
    Catalog #: 10-1976  |  CAS #: 1325147-19-0
    Formal Name:


  • 3'-Cholesteryl-TEG CPG
    3'-Cholesteryl-TEG CPG (20-2975)
    Catalog #: 20-2975
    Formal Name:

    1-Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-glyceryl-2-O-succinoyl-long chain alkylamino-CPG

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3 Product Results