1-Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-glyceryl-2-O-succinoyl-long chain alkylamino-CPG
Potential therapeutic oligonucleotides must permeate the cell membrane for optimal activity. The addition of lipophilic groups to an oligonucleotide would be expected to enhance cellular uptake/membrane permeation. The use of Cholesterol-labelled oligos and the consequent improvement in activity has been described. We have designed our Cholesteryl products with triethyleneglycol (TEG) spacers for maximum solubility.
|Storage||Freezer storage, -10 to -30°C, dry|
Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε Zumrut, H., Yang, Z., Williams, N., Arizala, J. D. rosario, Batool, S., Benner, S., & Mallikaratchy, P.