Psoralen Labeling of Oligonucleotides

Psoralen C2 at the 5’-terminus of an oligonucleotide serves effectively as a cross-linking reagent in double-stranded oligonucleotides.  The 6 atom spacer arm of Psoralen C6 allows cross-linking with a triplex oligonucleotide strand.  Click Chemistry with psoralen azide and one of our many nucleosidic and non-nucleosidic alkyne derivatives has the potential to generate a variety of practical cross-linkers.  The well known reversible cross-linking behavior of psoralen with an adjacent thymidine residue could be very useful.

3 Product Results
 
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  • Psoralen C2 Phosphoramidite
    Psoralen C2 Phosphoramidite (10-1982)
    Catalog #: 10-1982  |  CAS #: 126221-83-8
    Formal Name: 2-[4'-(hydroxymethyl)-4,5',8-trimethylpsoralen]-ethyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
  • Psoralen C6 Phosphoramidite
    Psoralen C6 Phosphoramidite (10-1983)
    Catalog #: 10-1983  |  CAS #: 518046-08-7
    Formal Name: 6-[4'-(Hydroxymethyl)-4,5',8-trimethylpsoralen]-hexyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
  • Psoralen Azide
    Psoralen Azide (50-2009)
    Catalog #: 50-2009  |  CAS #: 1489190-74-0
    Formal Name: 4'-Azidomethyl-4,5',8-trimethylpsoralen
 
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