TOM-protected phosphoramidites and supports for RNA synthesis

RNA synthesis using monomers containing the 2’-O-TriisopropylsilylOxyMethyl (TOM) group (TOM-Protecting-Group™) is characterized by very high coupling efficiency along with fast, simple deprotection. High coupling efficiency is achieved because the TOM-Protecting-Group exhibits lower steric hindrance than the 2’-O-t-butyldimethylsilyl (TBDMS) group used in our alternative RNA monomers. Fast and reliable deprotection is achieved using methylamine in ethanol/water at room temperature. A further feature of the TOM-Protecting-Group is that during basic steps it can not undergo 2’ to 3’ migration. This migration under basic conditions leads to non-biologically active 2’-5’ linkages when using the TBDMS group. These features allow the TOM-Protected monomers to produce longer oligonucleotides. TOM-Protected RNA monomers are also fully compatible with minor bases with 2’-O-TBDMS protection.

8 Product Results
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  • A-TOM-CE Phosphoramidite
    A-TOM-CE Phosphoramidite (10-3004)
    Catalog #: 10-3004  |  CAS #: 253586-13-9
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Adenosine,2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • C-TOM-CE Phosphoramidite
    C-TOM-CE Phosphoramidite (10-3014)
    Catalog #: 10-3014  |  CAS #: 253586-12-8
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • G-TOM-CE Phosphoramidite
    G-TOM-CE Phosphoramidite (10-3024)
    Catalog #: 10-3024  |  CAS #: 253586-14-0
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Guanosine,2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • U-TOM-CE Phosphoramidite
    U-TOM-CE Phosphoramidite (10-3034)
    Catalog #: 10-3034  |  CAS #: 220230-62-6
    Formal Name:


  • Ac-A-RNA-CPG
    Ac-A-RNA-CPG (20-3304)
    Catalog #: 20-3304
    Formal Name:

    5'-Dimethoxytrityl-N-acetyl-Adenosine,2'-O-acetyl-3'-succinoyl-long chain alkylamino-CPG

  • Ac-C-RNA-CPG
    Ac-C-RNA-CPG (20-3315)
    Catalog #: 20-3315
    Formal Name:

    5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-acetate-3'-succinoyl-long chain alkylamino-CPG

  • Ac-G-RNA-CPG
    Ac-G-RNA-CPG (20-3324)
    Catalog #: 20-3324
    Formal Name:

    5'-Dimethoxytrityl-N-acetyl-Guanosine,2'-O-acetyl-3'-succinoyl-long chain alkylamino-CPG

    U-RNA-CPG (20-3330)
    Catalog #: 20-3330
    Formal Name: 5'-Dimethoxytrityl-Uridine,2'-acetate-3'-succinoyl-long chain alkylamino-CPG
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