Standard RNA Phosphoramidites and Supports

TOM-Protected RNA Phosphoramidites

RNA synthesis using monomers containing the 2’-O-TriisopropylsilylOxyMethyl (TOM) group (TOM-Protecting-Group™) is characterized by very high coupling efficiency along with fast, simple deprotection. High coupling efficiency is achieved because the TOM-Protecting-Group exhibits lower steric hindrance than the 2’-O-t-butyldimethylsilyl (TBDMS) group used in our alternative RNA monomers. Fast and reliable deprotection is achieved using methylamine in ethanol/water at room temperature. A further feature of the TOM-Protecting-Group is that during basic steps it can not undergo 2’ to 3’ migration. This migration under basic conditions leads to non-biologically active 2’-5’ linkages when using the TBDMS group. These features allow the TOM-Protected monomers to produce longer oligonucleotides. TOM-Protected RNA monomers are also fully compatible with minor bases with 2’-O-TBDMS protection.

TBDMS-Protected RNA Phosphoramidites

Glen Research CE (ß-cyanoethyl) Phosphoramidites for RNA synthesis are produced and packaged to ensure the highest performance on commercial synthesizers. Every batch is accompanied by a Certificate of Analysis and an HPLC trace, showing the results of our QC testing. RNA Phosphoramidites are synthesis-tested with a minimum coupling efficiency of 97%. Glen Research RNA monomers are packaged in industry standard vials which are specially cleaned to eliminate particulate contamination. These monomers are available in a variety of packs, including high throughput (HT) and low cost (LC). An UltraMild set is also available for situations where sensitive bases are in use. Dmf-G (10-3029) has been discontinued and may be substituted with Ac-G (10-3025).

17 Product Results
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  • Pac-A-CE Phosphoramidite
    Pac-A-CE Phosphoramidite (10-3000)
    Catalog #: 10-3000  |  CAS #: 121058-86-4
    Formal Name: 5'-Dimethoxytrityl-N-phenoxyacetyl-Adenosine,2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • Bz-A-CE Phosphoramidite
    Bz-A-CE Phosphoramidite (10-3003)
    Catalog #: 10-3003  |  CAS #: 104992-55-4
    Formal Name: 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • A-TOM-CE Phosphoramidite
    A-TOM-CE Phosphoramidite (10-3004)
    Catalog #: 10-3004  |  CAS #: 253586-13-9
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Adenosine,2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • C-TOM-CE Phosphoramidite
    C-TOM-CE Phosphoramidite (10-3014)
    Catalog #: 10-3014  |  CAS #: 253586-12-8
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • Ac-C-CE Phosphoramidite
    Ac-C-CE Phosphoramidite (10-3015)
    Catalog #: 10-3015  |  CAS #: 121058-88-6
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • iPr-Pac-G-CE Phosphoramidite
    iPr-Pac-G-CE Phosphoramidite (10-3021)
    Catalog #: 10-3021  |  CAS #: 689283-85-0
    Formal Name: 5'-Dimethoxytrityl-N-p-isopropylphenoxyacetyl-Guanosine,2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • G-TOM-CE Phosphoramidite
    G-TOM-CE Phosphoramidite (10-3024)
    Catalog #: 10-3024  |  CAS #: 253586-14-0
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Guanosine,2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • Ac-G-CE Phosphoramidite
    Ac-G-CE Phosphoramidite (10-3025)
    Catalog #: 10-3025  |  CAS #: 944138-03-8
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Guanosine,2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • U-CE Phosphoramidite
    U-CE Phosphoramidite (10-3030)
    Catalog #: 10-3030  |  CAS #: 118362-03-1
    Formal Name: 5'-Dimethoxytrityl-Uridine,2'-O-TBDMS,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • U-TOM-CE Phosphoramidite
    U-TOM-CE Phosphoramidite (10-3034)
    Catalog #: 10-3034  |  CAS #: 220230-62-6
    Formal Name:


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