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2'-OMe-U-CE Phosphoramidite - (10-3130)

5'-Dimethoxytrityl-Uridine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

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10-3130

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Product Specifications

Formula:

C₄₀H₄₉N₄O₉P

M.W.:

760.82

F.W.:

320.2

CAS Number:

110764-79-9

5'-Dimethoxytrityl-Uridine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Description

Glen Research 2'-OMe-RNA CE (ß-cyanoethyl) Phosphoramidites are designed to produce synthetic oligonucleotides containing nuclease resistant 2'-O-methyl ribonucleotide linkages. Deprotection, isolation and handling of 2'-O-methyl oligonucleotides are identical to the procedures for oligodeoxynucleotides.

Details

Usage

Coupling: 6 minute coupling time recommended
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

Specifications
Diluent	Anhydrous Acetonitrile
Recommended Storage	Refrigerated storage, maximum of 2-8°C, dry
Stability In Solution	3-5 days

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394

Catalog #	Pack Size	Grams/Pack	0.1M Dil. (mL)	Approximate Number of Additions
				LV40	LV200	40nm	0.2μm	1μm	10μm
10-3130-02	0.25 g	.25grams	3.29	96.33	57.8	36.13	26.27	19.27	4.82
10-3130-05	0.5 g	.5grams	6.57	205.67	123.4	77.13	56.09	41.13	10.28
10-3130-10	1.0 g	1grams	13.14	424.67	254.8	159.25	115.82	84.93	21.23
10-3130-90	100 µmol	.076grams	1	20	12	7.5	5.45	4	1

Expedite

Catalog #	Pack Size	Grams/Pack	Dilution (mL)	Approximate Number of Additions
				Molarity	50nm	0.2μm	1μm	15μm
10-3130-02	0.25 g	.25grams	4.9	0.07	91.6	57.25	41.64	5.73
10-3130-05	0.5 g	.5grams	9.81	0.07	189.8	118.63	86.27	11.86
10-3130-10	1.0 g	1grams	19.62	0.07	386	241.25	175.45	24.13
10-3130-90	100 µmol	.076grams	1.5	0.07	23.6	14.75	10.73	1.48