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2'-OMe-ibu-G-CE Phosphoramidite - (10-3120)

5'-Dimethoxytrityl-N-isobutyryl-Guanosine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

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10-3120

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Product Specifications

Formula:

C₄₅H₅₆N₇O₉P

M.W.:

869.97

F.W.:

359.24

CAS Number:

150780-67-9

5'-Dimethoxytrityl-N-isobutyryl-Guanosine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Description

Glen Research 2'-OMe-RNA CE (ß-cyanoethyl) Phosphoramidites are designed to produce synthetic oligonucleotides containing nuclease resistant 2'-O-methyl ribonucleotide linkages. Deprotection, isolation and handling of 2'-O-methyl oligonucleotides are identical to the procedures for oligodeoxynucleotides.

Details

Usage

Coupling: 6 minute coupling time
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

Specifications
Diluent	Anhydrous Acetonitrile
Recommended Storage	Refrigerated storage, maximum of 2-8°C, dry
Stability In Solution	3-5 days

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394

Catalog #	Pack Size	Grams/Pack	0.1M Dil. (mL)	Approximate Number of Additions
				LV40	LV200	40nm	0.2μm	1μm	10μm
10-3120-02	0.25 g	.25grams	2.87	82.33	49.4	30.88	22.45	16.47	4.12
10-3120-05	0.5 g	.5grams	5.75	178.33	107	66.88	48.64	35.67	8.92
10-3120-10	1.0 g	1grams	11.49	369.67	221.8	138.63	100.82	73.93	18.48
10-3120-90	100 µmol	.087grams	1	20	12	7.5	5.45	4	1

Expedite

Catalog #	Pack Size	Grams/Pack	Dilution (mL)	Approximate Number of Additions
				Molarity	50nm	0.2μm	1μm	15μm
10-3120-02	0.25 g	.25grams	4.29	0.07	79.4	49.63	36.09	4.96
10-3120-05	0.5 g	.5grams	8.58	0.07	165.2	103.25	75.09	10.33
10-3120-10	1.0 g	1grams	17.16	0.07	336.8	210.5	153.09	21.05
10-3120-90	100 µmol	.087grams	1.5	0.07	23.6	14.75	10.73	1.48