Glen Research has committed to adding to our product line azide analogues of our most popular tags, in addition to interesting reagents which are not compatible with routine oligonucleotide synthesis. HEX and TET are two of our most popular fluorescein-based dyes for labelling oligonucleotides. We are happy to offer 6-HEX (3) and 6-TET (4) Azides for use in click conjugations.
In Figure 5, the high conjugation efficiency of 6-HEX Azide is illustrated. Virtually 100% efficiency was achieved in a copper-free click with an oligo modified at the 5' terminus using 5’-DBCO-TEG Phosphoramidite.