Glen Report 24.24: New Product - Alkyne-Modifier Serinol Phosphoramidite
Two of our products for Click Chemistry have proved to be especially popular over the years. For simple 5'-alkyne modification, our 5'-Hexynyl Phosphoramidite (1) is an inexpensive option. However, this product does not allow DMT-On purification. More recently, our 3’-Alkyne-Modifier Serinol CPG (2) has also proved popular as a support for alkyne modification of the 3' terminus.
We are now offering Alkyne-Modifier Serinol Phosphoramidite (3), also based on our proprietary serinol backbone, which can be used to modify the 5' terminus or any other position(s) within an oligonucleotide while still being compatible with DMT-On purification. Unlike 5'-Hexynyl Phosphoramidite, which is a viscous oil, Alkyne-Modifier Serinol Phosphoramidite is a solid that also allows easy weighing of the product by our customers prior to use.
Alkyne-Modifier Serinol Phosphoramidite is used with a coupling time of 3 minutes and is compatible with most popular procedures for oligonucleotide deprotection - AMA, 10 minutes/65°C or ammonium hydroxide, 17h/RT or 2h/65°C.



Product Information
5'-Hexynyl Phosphoramidite (10-1908)
Alkyne-Modifier Serinol Phosphoramidite (10-1992)
3'-Alkyne-Modifier Serinol CPG (20-2992)
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- Glen Report 24.22: New Product - DBCO-dT for Copper-Free Click Chemistry
- Glen Report 24.23: Antisense Trimer Phosphoramidites - A New Method for Mutagenesis Spanning Entire Genes
- Glen Report 24.24: New Product - Alkyne-Modifier Serinol Phosphoramidite
- Glen Report 24.25: Technical Brief - Reagents for 5’-Labeling of microRNAs
- Glen Report 24.26: Advances in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition (CuAAC)
- Glen Report 24.27: Introducing Oligo-Click Kits
- Glen Report 24.28: Technical Brief: FRETmatrix – A Method for Simulation and Analysis of FRET in Oligos
- Glen Report 24.29: Technical Brief: Which 5'-Amino-Modifier?
- Glen Report 24.210: Technical Brief - Improved Conditions for Deprotecting 5-Formyl-dC
- Glen Report 24.211: New Products: Universal HybridCPG™ Solid Supports