Home Products DNA & RNA Nucleosides, Analogs, and Supports Nucleoside Analog Phosphoramidites DNA Nucleoside Analogs Analog Phosphoramidites for Structural Studies Halogenated Nucleosides 5-Br-dU-CPG

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5-Br-dU-CPG - (20-2090)

5'-Dimethoxytrityl-5-bromo-2'-deoxyUridine, 2'-succinoyl-long chain alkylamino-CPG

Description

Brominated and iodinated nucleosides are used in crystallography studies of oligonucleotide structure. They are also photolabile and are used for cross-linking studies to probe the structure of protein-DNA complexes. Antibodies exist to Br-dU and oligonucleotides containing Br-dU can be used as probes.

Details

Usage

Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
Deprotection: Deprotect with Ammonium Hydroxide at room temperature for 24hours