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5-I-dC-CE Phosphoramidite - (10-1081)

5'-Dimethoxytrityl-N-benzoyl-5-iodo-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

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10-1081

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Product Specifications

Formula:

C₄₆H₅₁IN₅O₈P

M.W.:

959.83

F.W.:

415.08

CAS Number:

178925-44-5

5'-Dimethoxytrityl-N-benzoyl-5-iodo-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Description

Brominated and iodinated nucleosides are used in crystallography studies of oligonucleotide structure. They are also photolabile and are used for cross-linking studies to probe the structure of protein-DNA complexes. Antibodies exist to Br-dU and oligonucleotides containing Br-dU can be used as probes.

Details

Usage

Coupling: No changes needed from standard method recommended by synthesizer manufacturer.
Deprotection: Mild Ammonium Hyrdoxide for 24 hours at room temperature.