Home Products Modification and Labeling Products for Oligonucleotide Backbone Modification 5' -> 3' Synthesis Phosphoramidites and Supports 5'-3' Synthesis Phosphoramidites dSpacer-5’-CE Phosphoramidite

dSpacer-5’-CE Phosphoramidite - (10-4191)

3'-O-Dimethoxytrityl-1',2'-Dideoxyribose-5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

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10-4191

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Product Specifications

Formula:

C₃₅H₄₅N₂O₆P

M.W.:

620.73

F.W.:

180.1

CAS Number:

401813-16-9

3'-O-Dimethoxytrityl-1',2'-Dideoxyribose-5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Description

In oligonucleotide applications, there is often a need to introduce blocking groups on the 3’-end and sometimes at the 5’-end as well. These blocking groups can provide exonuclease protection or prevent polymerase extension. One such blocking group is an inverted dSpacer, which can be incorporated with dSpacer-5’-CE Phosphoramidite during standard 3’ to 5’ syntheses.

Details

Usage

Coupling: No changes needed from standard method recommended by synthesizer manufacturer.
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.