2'-MOE RNA Phosphoramidites

Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U.

 
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  • A-2'-MOE-Phosphoramidite
    A-2'-MOE-Phosphoramidite (10-3200)
    Catalog #: 10-3200  |  CAS #: 251647-53-7
    Formal Name:

    5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-N6-benzoyl-adenosine -3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

  • 5-Me-C-2'-MOE-Phosphoramidite
    5-Me-C-2'-MOE-Phosphoramidite (10-3211)
    Catalog #: 10-3211  |  CAS #: 163759-94-2
    Formal Name:

    5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-N4-benzoyl- cytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

  • G-2'-MOE-Phosphoramidite
    G-2'-MOE-Phosphoramidite (10-3220)
    Catalog #: 10-3220  |  CAS #: 251647-55-9
    Formal Name:

    5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-N2-isobutyryl- guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

  • 5-Me-U-2'-MOE-Phosphoramidite
    5-Me-U-2'-MOE-Phosphoramidite (10-3231)
    Catalog #: 10-3231  |  CAS #: 163878-63-5
    Formal Name:

    5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-5-methyl-uridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

 
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4 Product Results