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8-Amino-dA-CE Phosphoramidite - (10-1086)

5'-Dimethoxytrityl-N6,N8-bis(dimethylaminomethylidine)-8-amino-2'-deoxyAdenosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

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10-1086

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Product Specifications

Formula:

C₄₆H₅₉N₁₀O₆P

M.W.:

879.01

F.W.:

328.22

CAS Number:

211676-21-0

5'-Dimethoxytrityl-N6,N8-bis(dimethylaminomethylidine)-8-amino-2'-deoxyAdenosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Description

8-Amino-dA and 8-amino-dG are useful in triplex formation due to the presence of the additional amino groups. 2'-DeoxyXanthosine (dX) is a naturally occurring nucleoside that may be derived from oxidative deamination of 2'-deoxyGuanosine (dG). dX has a similar bonding pattern to thymidine and it may base pair with dA, with such purine-purine interactions causing duplex distortion. dX also featured in attempts to extend the genetic alphabet with a new base pair of dX and pyrimidine-2,4-diamine nucleoside. dX has also interested researchers in the field of DNA damage and repair since it is a product of nitric oxide-induced mutagenesis.

Details

Usage

Coupling: No changes needed from standard method recommended by synthesizer manufacturer.
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

Specifications
Diluent	Anhydrous Acetonitrile
Recommended Storage	Refrigerated storage, maximum of 2-8°C, dry
Stability In Solution	2-3 days

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394

Catalog #	Pack Size	Grams/Pack	0.1M Dil. (mL)	Approximate Number of Additions
				LV40	LV200	40nm	0.2μm	1μm	10μm
10-1086-02	0.25 g	.25grams	2.84	81.33	48.8	30.5	22.18	16.27	4.07
10-1086-90	100 µmol	.088grams	1	20	12	7.5	5.45	4	1
10-1086-95	50 µmol	.044grams	0.5	3.33	2	1.25	0.91	0.67	0.17

Expedite

Catalog #	Pack Size	Grams/Pack	Dilution (mL)	Approximate Number of Additions
				Molarity	50nm	0.2μm	1μm	15μm
10-1086-02	0.25 g	.25grams	4.24	0.07	78.4	49	35.64	4.9
10-1086-90	100 µmol	.088grams	1.5	0.07	23.6	14.75	10.73	1.48
10-1086-95	50 µmol	.044grams	0.75	0.07	8.6	5.38	3.91	0.54