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This product has been discontinued.

Coupling: 12 minute coupling time recommended.
Deprotection: RNA Deprotection-see bulletin

We have discontinued this product permanently. Please find recommended products below.

Pyridin-2-one-CE Phosphoramidite - (10-3012)

5'-Dimethoxytrityl-pyridin-2-one-riboside, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Description

Ribozyme activity is substantially affected by the substitution of modified pyrimidine bases. Zebularine (pyrimidin-2-one ribonucleoside) may be regarded as a Cytidine derivative lacking the exocyclic amino group. Zebularine and Pyridin-2-one Ribonucleoside, the 3-deaza analogue of Zebularine, are prime candidates for use in evaluating ribozyme activity and function. It should be noted that Zebularine is mildly fluorescent, absorbing at 298nm and emitting at 367nm.

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