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Palmitate Phosphoramidite - (10-1978)

Palmityl-6-aminohexyl [(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

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10-1978

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Product Specifications

Formula:

C₃₁H₆₂N₃O₃P

M.W.:

555.83

F.W.:

417.57

CAS Number:

1772522-18-5

Palmityl-6-aminohexyl [(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Description

Palmitate Phosphoramidite is a saturated fatty acid with a 16-carbon backbone. This 5’-modification is a lipophilic group. When incorporated into a synthetic oligonucleotide, Palmitate conjugates offer enhanced cellular uptake and delivery to extrahepatic tissues.

Details

Usage

Coupling: 6 minute coupling time recommended
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

Specifications
Diluent	Anhydrous Acetonitrile/Dichloromethane 1:3 (v/v)
Recommended Storage	Freezer storage, -10 to -30°C, dry
Stability In Solution	1-2 Days

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394

Catalog #	Pack Size	Grams/Pack	0.1M Dil. (mL)	Approximate Number of Additions
				LV40	LV200	40nm	0.2μm	1μm	10μm
10-1978-95	50 µmol	.028grams	0.5	3.33	2	1.25	0.91	0.67	0.17
10-1978-90	100 µmol	.056grams	1	20	12	7.5	5.45	4	1
10-1978-02	0.25 g	0.25grams	4.5	136.67	82	51.25	37.27	27.33	6.83