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Palmitate Serinol Phosphoramidite - (10-1990)

3-Dimethoxytrityloxy-2-(3-palmitamidopropanamido)propyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

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10-1990

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Product Specifications

Formula:

C₅₂H₇₉N₄O₇P

M.W.:

903.2

F.W.:

462.57

3-Dimethoxytrityloxy-2-(3-palmitamidopropanamido)propyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

Description

Palmitate Serinol Phosphoramidite structure features a saturated fatty acid with a 16-carbon chain. When incorporated into synthetic oligonucleotides, palmitate enhances cellular uptake and activity in various tissues. The Serinol linker allows for the incorporation of modifications at the 3′-end, internally, and at the 5′-end during oligonucleotide synthesis.

Details

Usage

Coupling: 6 minute coupling time recommended
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

Specifications
Diluent	Anhydrous Acetonitrile
Recommended Storage	Freezer storage, -10 to -30°C, dry
Stability In Solution	1-2 Days

Dilution/Coupling Data

The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.

ABI 392/394

Catalog #	Pack Size	Grams/Pack	0.1M Dil. (mL)	Approximate Number of Additions
				LV40	LV200	40nm	0.2μm	1μm	10μm
10-1990-95	50 µmol	0.05	0.5	3.3	2	1.2	0.9	0.6	0.1
10-1990-90	100 µmol	0.09	1	120	12	7.5	5.4	4	1
10-1990-02	0.25 g	0.25	2.77	79	47.4	29.6	21.5	15.8	3.9

Expedite

Catalog #	Pack Size	Grams/Pack	Dilution (mL)	Approximate Number of Additions
				Molarity	50nm	0.2μm	1μm	15μm
10-1990-95	50 µmol	0.05	0.75	0.07	8.6	5.3	3.9	0.5
10-1990-90	100 µmol	0.09	1.5	0.07	23.6	14.7	10.7	1.4
10-1990-02	0.25 g	0.25	4.13	0.07	76.2	47.6	34.6	4.7