Home Products Modification and Labeling Copper-free Click Chemistry Reagents Copper Chelators THPTA Ligand

THPTA Ligand - (50-1004)

Tris(3-hydroxypropyltriazolylmethyl)amine

As low as $50.00

In stock

Only %1 left

default

50-1004

Product	Options
	To retrieve a catalog number, please select a pack size and format: Copy link to this configuration Size Format See Compatibility Chart 4. Select Your Quantity: Request a quote 3. Price

Product Specifications

Formula:

C₁₈H₃₂N₁₀O₃

M.W.:

434.5

CAS Number:

760952-88-3

Tris(3-hydroxypropyltriazolylmethyl)amine

Description

TBTA covers most of the practical applications for Click Chemistry except for a completely aqueous conjugation reaction. The benefits of a completely aqueous reaction include the biological labeling of live cells or the labeling of proteins without the concern of denaturing secondary structures. The water-soluble tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) click ligand further simplifies Click Chemistry by allowing the entire reaction to be run in water, affording biological compatibility for Click reactions. The THPTA ligand binds Cu(I), blocking the bioavailability of Cu(I) and ameliorating the potential toxic effects while maintaining the catalytic effectiveness in click conjugations. The THPTA ligand was effectively used to label live cells with high efficiency while maintaining cell viability.4

Details