Glen Research offers alternative solvents and reagents in suitable bottles and formulations for use on various DNA synthesizers. All solvents and reagents are prepared to our exacting specifications to ensure the highest coupling efficiencies and are passed through a 0.2 micron filter during packaging to eliminate particulate contamination. Glen Research offers the activators in powder form for later dissolution in anhydrous acetonitrile or as a prepared solution.
Coupling: No changes needeed
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.
Controlled room temperature or lower, dry
A license may be required from Ionis Pharmaceuticals, Inc. to use DCI as an activator in oligonucleotide synthesis as claimed in U.S. Patent Numbers 6,031,092; 6,160,109 and foreign equivalents.