C-Serinol-CE Phosphoramidite - (10-2391)
3-Dimethoxytrityloxy-2-(cytosine-1-acetamido)propyl- 1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
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10-2391
3-Dimethoxytrityloxy-2-(cytosine-1-acetamido)propyl-
1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
Description
Serinol nucleic acid (SNA) is an acyclic phosphodiester backbone based on serinol (2-amino-1,3-propanediol). It shares the same three carbon skeleton as ribose and has nucleobases that are one atom further away from the skeleton than standard nucleic acids. SNA hybridizes to both DNA and RNA.
Details
Usage
- Coupling: No changes needed from standard method recommended by synthesizer manufacturer.
- Deprotection: Ammonium Hydroxide for 4-8 hours at 55 °C.
| Specifications | |
|---|---|
| Diluent | Anhydrous Acetonitrile |
| Recommended Storage | Freezer storage, -10 to -30°C, dry |
| Stability In Solution | 1-2 Days |
Dilution/Coupling Data
The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.
ABI 392/394
| Catalog # | Pack Size | Grams/Pack | 0.1M Dil. (mL) | Approximate Number of Additions | |||||
|---|---|---|---|---|---|---|---|---|---|
| LV40 | LV200 | 40nm | 0.2μm | 1μm | 10μm | ||||
| 10-2391-02 | 0.25 g | 0.25 | 2.94 | 84.7 | 50.8 | 31.7 | 23.1 | 16.9 | 4.2 |
| 10-2391-05 | 0.5 g | 0.5 | 5.89 | 183 | 109.8 | 68.6 | 49.9 | 36.6 | 9.1 |
Technical documents
Certificate of analysis
CoA search tool
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