5-Me-C-scpBNA™-CE Phosphoramidite - (10-2211)
5'-Dimethoxytrityl-N-benzoyl-5-methyl-(2'-O, 4'-C spirocyclopropylene)- Cytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
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10-2211
5'-Dimethoxytrityl-N-benzoyl-5-methyl-(2'-O, 4'-C spirocyclopropylene)-
Cytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Description
Spirocyclopropylene bridged nucleic acid (scpBNATM) is a tricyclic analog of locked nucleic acid (LNA). scpBNA exhibits high binding affinity as well as excellent metabolic stability, and these properties make scpBNA an excellent sugar modification for therapeutic applications.
Details
Usage
- Coupling: 3 minute coupling time recommended. Increase oxidation time 3 fold for optimal performance.
- Deprotection: No changes needed from standard method recommended by synthesizer manufacturer. Note: Deprotection in AMA (50:50 Ammonium hydroxide/MethylAmine) may result in a 4-5% 5-methyl-N4-methyl-C side product at the modification site.
| Specifications | |
|---|---|
| Diluent | DCM:Acetonitrile (1:1) |
| Recommended Storage | Freezer storage, -10 to -30°C, dry |
| Stability In Solution | 1-2 Days |
Dilution/Coupling Data
The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.
ABI 392/394
| Catalog # | Pack Size | Grams/Pack | 0.1M Dil. (mL) | Approximate Number of Additions | |||||
|---|---|---|---|---|---|---|---|---|---|
| LV40 | LV200 | 40nm | 0.2μm | 1μm | 10μm | ||||
| 10-2211-02 | 100 µmol | 0.09 | 1 | 20 | 12 | 7.5 | 5.4 | 4 | 1 |
| 10-2211-90 | 0.25 g | 0.25 | 2.7 | 79 | 47.4 | 29.6 | 21.5 | 15.8 | 3.9 |
Expedite
| Catalog # | Pack Size | Grams/Pack | Dilution (mL) | Approximate Number of Additions | ||||
|---|---|---|---|---|---|---|---|---|
| Molarity | 50nm | 0.2μm | 1μm | 15μm | ||||
| 10-2211-02 | 100 µmol | 0.09 | 1.5 | 0.7 | 23.6 | 14.7 | 10.7 | 1.4 |
| 10-2211-90 | 0.25 g | 0.25 | 4.1 | 0.7 | 76.4 | 47.7 | 34.7 | 15.8 |
Technical documents
Certificate of analysis
CoA search tool
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Intellectual Property
scpBNA™ is a trademark owned by Luxna Biotech Co., Ltd. (Luxna).
scpBNA™ phosphoramidites (Products) are protected by WO2015/125783A1, WO2020/204022A1 and their foreign patents/applications controlled by Luxna.
Glen Research sells the Products under contract with Summit Pharmaceuticals International Corporation, which has the license from Luxna. The resale of the Products is prohibited. The Products can be used only for experimental or research use, and the uses of the Products, including processed products thereof, for any purposes other than experimental or research use is prohibited. The purchase of the Products does not grant any right for the Patents, except for experimental or research use. For any other use, the customer must obtain a license from Luxna (sales@luxnabiotech.co.jp, +81-6-6170-1228).
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