Glen Research’s Sulfurization Reagents are used to prepare phosphorothioate linkages using CE phosphoramidite chemistry. Each reagent exhibits the following attributes:
Sulfurizing Reagent II (3-((Dimethylamino-methylidene)amino)-3H-1,2,4-dithiazole-3-thione, DDTT) exhibits all the properties of Beaucage Reagent while adding stability in solution on the synthesizer AND offering strong ability to sulfurize RNA linkages. Sulfurizing Reagent II is available in powder form and as a stable solution.
|Diluent||60% pyridine/40% Acetonitrile (fully dissolve in pyridine first, see notes below*)|
|Storage||Controlled room temperature or lower, dry|
|Stability||At least 6 months|