Branching Phosphoramidites

A branching monomer is  required to construct comb-like oligonucleotide probes.  The developers of the comb system from Chiron Corporation evaluated3 several protecting groups for the branch point and chose levulinyl (LEV), which is specifically removed using a reagent containing hydrazine hydrate, acetic acid and pyridine.

1 Product Results
 
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  • 5-Me-dC Brancher Phosphoramidite
    5-Me-dC Brancher Phosphoramidite (10-1018)
    Catalog #: 10-1018  |  CAS #: 135887-12-6
    Formal Name:

    5'-Dimethoxytrityl-N4-(O-levulinyl-6-oxyhexyl)-5-Methyl-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

 
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