Psoralen Labeling

Psoralen C2 at the 5’-terminus of an oligonucleotide serves effectively as a cross-linking reagent in double-stranded oligonucleotides.  The 6 atom spacer arm of Psoralen C6 allows cross-linking with a triplex oligonucleotide strand.  Click Chemistry with psoralen azide and one of our many nucleosidic and non-nucleosidic alkyne derivatives has the potential to generate a variety of practical cross-linkers.  The well known reversible cross-linking behavior of psoralen with an adjacent thymidine residue could be very useful.

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  1. Label/Modifier Type Psoralen Remove This Item
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