Analog Phosphoramidites in Large Scale Oligonucleotide Synthesis

The most common side reaction during deprotection of oligonucleotides on a large scale is the alkylation of dT residues by acrylonitrile, formed by ß-elimination of the cyanoethyl phosphate protecting groups, to generate N3-cyanoethyl-dT

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  • N3-Cyanoethyl-dT
    N3-Cyanoethyl-dT (10-1531)
    Catalog #: 10-1531
    Formal Name: 5'-Dimethoxytrityl-N3-(2-cyanoethyl)-2'-deoxyThymidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
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