Large Scale Synthesis

The most common side reaction during deprotection of oligonucleotides on a large scale is the alkylation of dT residues by acrylonitrile, formed by ß-elimination of the cyanoethyl phosphate protecting groups, to generate N3-cyanoethyl-dT

 
per page
  • N3-Cyanoethyl-dT
    N3-Cyanoethyl-dT (10-1531)
    Catalog #: 10-1531
    Formal Name: 5'-Dimethoxytrityl-N3-(2-cyanoethyl)-2'-deoxyThymidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
 
per page
1 Product Results