Halogentated Nucleosides

Brominated and iodinated nucleosides are used in X-ray crystallography studies of oligonucleotide structure.  They are also photolabile and are used for cross-linking studies to probe the structure of protein-DNA complexes.  Antibodies exist to Br-dU and oligonucleotides containing Br-dU can be used as probes.  5-Fluoro-dU can be used as a non-photoreactive alternative to 5-Br-dU with similar electron density.  5-F-dU base pairs more strongly that T to both dA and the dG mismatch.  It is also useful for probing DNA structure using 19F NMR spectroscopy.

7 Product Results
 
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  • 8-Br-dA-CE Phosphoramidite
    8-Br-dA-CE Phosphoramidite (10-1007)
    Catalog #: 10-1007  |  CAS #: 207906-54-5
    Formal Name: 5'-Dimethoxytrityl-N6-dimethylaminomethylidene-8-bromo-2'-deoxyAdenosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 8-Br-dG-CE Phosphoramidite
    8-Br-dG-CE Phosphoramidite (10-1027)
    Catalog #: 10-1027  |  CAS #: 198080-37-4
    Formal Name: 5'-Dimethoxytrityl-N2-dimethylaminomethylidene-8-bromo-2'-deoxyGuanosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5-Br-dC-CE Phosphoramidite
    5-Br-dC-CE Phosphoramidite (10-1080)
    Catalog #: 10-1080  |  CAS #: 178925-43-4
    Formal Name: 5'-Dimethoxytrityl-N-benzoyl-5-bromo-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5-I-dC-CE Phosphoramidite
    5-I-dC-CE Phosphoramidite (10-1081)
    Catalog #: 10-1081  |  CAS #: 178925-44-5
    Formal Name: 5'-Dimethoxytrityl-N-benzoyl-5-iodo-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5-Br-dU-CE Phosphoramidite
    5-Br-dU-CE Phosphoramidite (10-1090)
    Catalog #: 10-1090
    Formal Name: 5'-Dimethoxytrityl-5-bromo-2'-deoxyUridine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5-I-dU-CE Phosphoramidite
    5-I-dU-CE Phosphoramidite (10-1091)
    Catalog #: 10-1091  |  CAS #: 178925-48-9
    Formal Name: 5'-Dimethoxytrityl-5-iodo-2'-deoxyUridine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5-Br-dU-CPG
    5-Br-dU-CPG (20-2090)
    Catalog #: 20-2090
    Formal Name: 5'-Dimethoxytrityl-5-bromo-2'-deoxyUridine, 2'-succinoyl-long chain alkylamino-CPG
 
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