RNA Supports for TOM RNA Synthesis

RNA synthesis using monomers containing the 2’-O-TriisopropylsilylOxyMethyl (TOM) group (TOM-Protecting-Group™) is characterized by very high coupling efficiency along with fast, simple deprotection.  High coupling efficiency is achieved because the TOM-Protecting-Group exhibits lower steric hindrance than the 2’-O-t-butyldimethylsilyl (TBDMS) group used in our alternative RNA monomers.  Fast and reliable deprotection is achieved using methylamine in ethanol/water at room temperature.  A further feature of the TOM-Protecting-Group is that during basic steps it can not undergo 2’ to 3’ migration.  This migration under basic conditions leads to non-biologically active 2’-5’ linkages when using the TBDMS group.  These features allow the TOM-Protected monomers to produce longer oligonucleotides. 

3 Product Results
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  • Ac-A-RNA-CPG
    Ac-A-RNA-CPG (20-3304)
    Catalog #: 20-3304
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Adenosine,2'-O-acetyl-3'-succinoyl-long chain alkylamino-CPG
  • Ac-C-RNA-CPG
    Ac-C-RNA-CPG (20-3315)
    Catalog #: 20-3315
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-acetate-3'-succinoyl-long chain alkylamino-CPG
  • Ac-G-RNA-CPG
    Ac-G-RNA-CPG (20-3324)
    Catalog #: 20-3324
    Formal Name: 5'-Dimethoxytrityl-N-acetyl-Guanosine,2'-O-acetyl-3'-succinoyl-long chain alkylamino-CPG
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