Glen UnySupport

A recent development has been the use of a support based on a molecule which is “conformationally preorganized” to accelerate the dephosphorylation reaction.1,2  By using a rigid bicyclic molecule on the support, the rate of elimination is markedly faster than the original Universal Support.  The structure of Glen UnySupport™ is shown below.  The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligo synthesis.  Glen UnySupport is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection.  We are happy to offer Glen UnySupport in a variety of popular formats under license from Ionis Pharmaceuticals.

6 Product Results
 
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  • Glen UnySupport™ 500
    Glen UnySupport™ 500 (20-5040)
    Catalog #: 20-5040
    Formal Name: N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)-5-succinoyl long chain alkylamino CPG
  • Glen UnySupport™ 1000
    Glen UnySupport™ 1000 (20-5041)
    Catalog #: 20-5041
    Formal Name: N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)-5-succinoyl long chain alkylamino CPG
  • Glen UnySupport™ FC
    Glen UnySupport™ FC (22-5041)
    Catalog #: 22-5041
    Formal Name:

    N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)-5-diglycoloyl-long chain alkylamino CPG

  • High Load Glen UnySupport™
    High Load Glen UnySupport™ (25-5040)
    Catalog #: 25-5040
    Formal Name: N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)-5-succinoyl long chain alkylamino CPG
  • Glen UnySupport™ PS
    Glen UnySupport™ PS (26-5040)
    Catalog #: 26-5040
    Formal Name: N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)-5-succinoyl-polystyrene
  • Glen UnySupportTM HybridCPGTM
    Glen UnySupportTM HybridCPGTM (28-5040)
    Catalog #: 28-5040
    Formal Name: N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)-5-succinoyl long chain alkylamino HybridCPGTM
 
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