Glen UnySupport

A recent development has been the use of a support based on a molecule which is “conformationally preorganized” to accelerate the dephosphorylation reaction.1,2  By using a rigid bicyclic molecule on the support, the rate of elimination is markedly faster than the original Universal Support.  The structure of Glen UnySupport™ is shown below.  The N-phenyl version, developed at Isis Pharmaceuticals as UnyLinker™, is available from several companies for large scale oligo synthesis.  Glen UnySupport is the N-methyl version, which is preferred for high throughput oligonucleotide synthesis since methylamine rather than aniline is formed on deprotection.  We are happy to offer Glen UnySupport in a variety of popular formats under license from Ionis Pharmaceuticals.

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