Frequently Asked Questions (FAQ)

Below are answers to some of the most Frequently Asked Questions (FAQ) received by the Glen Research Technical Support Team:

• Do you provide Oligonucleotide synthesis services?
  • We don’t make oligos – Our customers do!
    We provide reagents for oligonucleotide syntheses, such as phosphoramidites, supports, and liquid reagents. We can ship our reagents to an oligonucleotide house of one’s choosing.

• How can I obtain SDS documents?
  • Please access SDS(s) under the “Resources” tab, or use the link below. Catalog numbers or chemical names are required.
    https://www.glenresearch.com/resources/sds/.

• What is the difference between the Certificate of Analysis (CofA) and the Analytical Report (AR)?
  • The CofA provides testing specifications and testing results, while the AR provides the testing results only.

• How can I obtain Certificates of Analysis (CofA’s) and Analytical Reports (AR's)?
  • Please access “Certificate of Analysis” under the “Resources” tab or use the link below. Catalog numbers and lot numbers are required.
    https://www.glenresearch.com/resources/certificate-of-analysis

• Do you provide custom synthesis?
  • Sometimes. We consider custom synthesis requests on a case by case basis. Custom syntheses are generally very expensive as multiple organic synthesis steps add up to a lot of labor costs. These projects will have minimum order quantities and often long lead times.
    Please contact the Technical Support Team ([email protected]) for all custom synthesis inquiries.

• What is the best cleavage and deprotection condition(s) for my oligonucleotide?
  • We provide a Deprotection Guide to assist our customs in picking the most efficient cleavage and deprotection condition(s) for their oligonucleotides at the link below:
    https://www.glenresearch.com/media/folio3/productattachments/application_guides/import/application_guides/Deprotection_Guide_20200110.pdf

• How do I purify my oligonucleotide?
  • There are many methods to purify your oligonucleotide. One of these methods is reverse phase cartridge purification, and we provide Glen-Pak™ cartridges for this purpose. One can find more information in the link below:
    https://www.glenresearch.com/products/oligonucleotide-purification-supplies/glen-pak-reverse-phase-purification-products.html

• Do you provide extinction coefficients for your products?
  • Yes, we have a list that covers most of our offerings at the following link:
    https://www.glenresearch.com/media/folio3/productattachments/technical_bulletin/Extinctions_20210112.pdf

• We are considering using one of your products as part of our oligonucleotide. Are there any IP restrictions we need to be aware of before committing? 
  • If we are aware of any IP restrictions for a specific product, we will note that information both on the product webpage as well as the certificate of analysis/analytical report.

• How do I select my fluorescent dyes and quenchers?
  • To select fluorescent dyes and quenchers, we recommend reviewing the link below for more information for the spectral characteristic’s of fluorescent dyes and quenchers: 
    https://www.glenresearch.com/spectral-characteristics-of-fluorescent-dyes