Palmitate Phosphoramidite is a saturated fatty acid with a 16-carbon backbone. This 5’-modification is a lipophilic group. When incorporated into a synthetic oligonucleotide, Palmitate conjugates offer enhanced cellular uptake and delivery to extrahepatic tissues.
Coupling: 6 minute coupling time recommended
Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.
Anhydrous Acetonitrile/Dichloromethane 1:3 (v/v)
Freezer storage, -10 to -30°C, dry
The table below show pack size data and, for solutions, dilution and approximate coupling based on normal priming procedures.