Glen Research sugar-modified nucleoside phosphoramidites are produced and packaged to ensure the highest performance on commercial synthesizers. Every batch is accompanied by a Certificate of Analysis and an HPLC trace, showing the results of our QC testing. Glen Research monomers are packaged in industry standard vials which are specially cleaned to eliminate particulate contamination.
2'-Deoxy-2’-fluoro-nucleosides adopt an RNA-type sugar conformation, presumably due to the high electronegativity of fluorine. Because of this sugar conformation, RNA duplexes (A-form) are generally more thermodynamically stable than DNA duplexes (B-form).
Arabinonucleosides are epimers of ribonucleosides with the chiral switch being at the 2’ position of the sugar residue. 2’-F-ANA adopts a more DNA-like B-type helix conformation, not through the typical C2’-endo conformation but, rather, through an unusual O4’-endo (east) pucker
Oligonucleotides containing LNA exhibit unprecedented thermal stabilities towards complementary DNA and RNA, which allows excellent mismatch discrimination.
Beta L-DNA is the mirror image version of naturally occurring D-DNA. L-DNA and D-DNA share identical structures that differ only in terms of stereochemistry and generally have identical physical and chemical properties.