Glen Research offers a wide range of products for research in structural studies.
A full battery of base, sugar and internucleotide modifications is available for aptamer development.
Ligation of an oligo containing a 5’-azide with an oligo containing a 3’-propargyl group using Click Chemistry leads to a triazole linkage that has been shown to have in vivo biocompatibility.
Glen Research offers a variety of halogenated nucleosides for your research needs.
Cytosine-5-methyltransferases are found in everything from archaebacteria to mammals and when the regulation of cytosine-5-methyltransferases goes awry, cancer can result. Glen Research offers products to aid in the study in the inhibition of DNA methyltransferases.
Glen Research offers a variety of products for the in situ synthesis of DNA analogs.
Large scale oligonucleotide synthesis is particularly challenging for a variety of reasons related obviously to synthesis scale. Novel high loading supports have had to be developed.
Products are available for research in non-cononical structures such as G-quadruplexes, triplex forming oligos, hairpins and cruciforms, and i-Motif structures.
Photo-control, the use of ultraviolet or visible light to control a reaction, has a number of advantages over other external stimuli.
The fluorescence of a nucleoside base is highly dependent on the environment of the base and the measurement of its fluorescence is a powerful and sensitive tool for the analysis of DNA and RNA structure.
A wide variety of modified DNA bases are available that may be used to investigate the effect on the activity of an oligonucleotide when key structural elements are changed.
Brominated and iodinated nucleosides are used in X-ray crystallography studies of oligonucleotide structure. They are also photolabile and are used for cross-linking studies to probe the structure of protein-DNA complexes. Antibodies exist to Br-dU and oligonucleotides containing Br-dU can be used as probes.
The Richert group at the University of Stuttgart has recently developed an ingenious method to selectively detect miRNAs on microarrays without interference from other RNA species.
A unique feature of 2'-5' linked oligonucleotides is their ability to bind selectively to complementary RNA.
