As research into the function of these naturally-occurring minor bases develops, there will be a need to synthesize oligonucleotides containing these minor bases.
A full line of products is available for research in RNA epigentics, one of the fastest growing fields in biology and cancer research is epigenetics.
UltraMild RNA synthesis reagents are available for use when RNA bases and labels are not compatible with ammonium hydroxide deprotection.
Our products for the synthesis of 2'-OMe-RNA are produced and packaged to ensure the highest performance on commercial oliognucleotide synthesizers.
Glen Research offers minor RNA phosphoramidites with either TOM or TBDMS protecting groups. Our RNA nucleoside analogs are produced and packaged to ensure the highest performance on commercial oligonucleotide synthesizers.
2'-Deoxy-2’-fluoro-nucleosides adopt an RNA-type sugar conformation, presumably due to the high electronegativity of fluorine. Because of this sugar conformation, RNA duplexes (A-form) are generally more thermodynamically stable than DNA duplexes (B-form).
PACE modifications have enjoyed a resurgence in interest as applied to the field of CRISPR gene editing.
Glen Research offers minor RNA phosphoramidites with TOM TBDMS protecting groups.
Glen Research offers minor RNA phosphoramidites with the TBDMS protecting group.