Halogenated Nucleosides

Brominated and iodinated nucleosides are used in X-ray crystallography studies of oligonucleotide structure.  They are also photolabile and are used for cross-linking studies to probe the structure of protein-DNA complexes.  Antibodies exist to Br-dU and oligonucleotides containing Br-dU can be used as probes.  5-Fluoro-dU can be used as a non-photoreactive alternative to 5-Br-dU with similar electron density.  5-F-dU base pairs more strongly that T to both dA and the dG mismatch.  It is also useful for probing DNA structure using 19F NMR spectroscopy.

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