Unnatural Base Pairs (ISO Bases)

Unnatural base pairs display unique abilities in duplex DNA and in nucleic acid and protein biosyntheses.  A standard Watson and Crick base pair is formed between iso-C and iso-G, but the hydrogen bonding pattern is quite different from the natural base pairs A-T and C-G. Iso-bases can, therefore, increase specificity of nucleic acid hydridization when introduced as a third base pair. It has also been demonstrated that iso-bases 5-Me-iso-dC and iso-dG can function as degenerate pyrimidine and purine bases, respectively. Iso-dG further functioned as a degenerate base opposite B (C, T, and G) ambiguous sites.

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  • dmf-isodG-CE Phosphoramidite
    dmf-isodG-CE Phosphoramidite (10-1078)
    Catalog #: 10-1078
    Formal Name: 5'-Dimethoxytrityl-O2-diphenylcarbamoyl-N6-dimethylaminomethylidene-2'-deoxyisoGuanosine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
 
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