3'-Glyceryl CPG

3-[(4,4'-Dimethoxytrityoxy)glyceryl-1-succinoyl]-long chain alkylamino-CPG

Product Specifications

F.W.:
154.06
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Description

With Glyceryl CPG, the 3’-terminus of an oligonucleotide is readily oxidized by sodium periodate to form a 3’-phosphoglycaldehyde. The aldehyde may be further oxidized to the corresponding carboxylic acid. Either the aldehyde or the carboxylate may be used for subsequent conjugation to amine-containing products.

Details

Usage

  • Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
  • Deprotection: Cleavage of the oligonucleotide from this support requires 2 hours at room temperature with ammonium hydroxide. Complete the deprotection using the protocol required by the nucleobases.
Specifications
Storage Freezer storage, -10 to -30°C, dry