3'-DBCO-Serinol CPG

3-Dimethoxytrityloxy-2-(6-oxo-6-(dibenzo[b,f]azacyclooct-4-yn-1-yl)-capramido)propyl-1-O-succinyl-long chain alkylamino-CPG

Product Specifications

F.W.:
468.45
Pore Size:
1000Å
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Description

Dibenzo-cyclooctyne (DBCO) enables copper-free click chemistry, and our 3'-DBCO-Serinol CPG allows customers to place a DBCO modification at the 3'-end of their oligo without the use of a universal support. We recommend using 0.5M CSO oxidizer to prevent loss of DBCO label when using standard iodine oxidation.

Details

Usage

  • Coupling: DBCO Serinol is susceptible to damage by iodine during oxidation. To prevent loss of the DBCO label, use 0.5M CSO in anhydrous acetonitrile (40-4632-xx) and a 3 minute oxidation time for best results.
  • Deprotection: Ammonium hydroxide for 2 hr at 65°C or as required by nucleobases.
Specifications
Storage Freezer storage, -10 to -30°C, dry