N-Methyl-succinimido[3,4-b]-7-oxabicyclo[2.2.1]heptane-6-(4,4'-dimethoxytrityloxy)- 5-succinoyl long chain alkylamino HybridCPGTM
Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
Deprotection: Solution phase: Ammonium Hydroxide:MethylAmine (AMA) 1:1 for 1 hour at 65°C or Ammonium Hydroxide for 8 hours at 55°C. For sensitive minor bases or dyes, Glen UnySupport may be eliminated with 50 mM Potassium Carbonate in Methanol in 17 hours at room temperature or with Tert-Butylamine/water 1:3 (v/v) for 4 hours at 60°C. Gas Phase: Methylamine gas for 30 minutes at 65°C at 30 psi.
Storage: Controlled room temperature or lower, dry
Stability in Solution: Not applicable
Please Note: This product is covered by US Patent 7,202,264 owned by Ionis Pharmaceuticals, Inc..