Coupling: No changes needed from standard method recommended by synthesizer manufacturer.
Deprotection: As required by nucleobases. Compatible with 30% ammonium hydroxide for 2 hours at 65°C, 17 hours at room temperature, AMA (ammonium hydroxide/40% methylamine 1:1) for 10 minutes at 65 °C and UltraMild deprotection conditions. Note extended deprotection in ammonium hydroxide (17 hours at 55 °C) will lead to some degradation.
Storage: Refrigerated storage, maximum of 2-8°C, dry
Stability in Solution: n/a
Please Note: GalNAc C3 products are sold under agreement with AM Chemicals LLC.