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*****Glen Research Glen Report*****
PROPYNYL-2'-OMe-RNA, Br-U, I-U
- ANTISENSE PROBES, CROSSLINKING
Researchers have continued to explore the potential uses of C-5
propynyl pyrimidine derivatives of oligonucleotides. Caltech
investigators1 have examined the effect of C-5 propynyl-dU on triple
helix formation. Groups from Gilead Sciences and The Agouron
Institute2 have measured the specific effect of a series of C-5
propyne oligonucleotides on HIV mRNA targets.
Br-U, I-U-CE Phosphoramidites
Interest in crosslinking experiments has not been restricted to DNA protein interactions and we have been asked to provide halogenated RNA monomers. The two Uridine derivatives 5-Br-U and 5-I-U4 are now available from Glen Research.
(1) N. Colocci and P.B. Dervan, J. Amer. Chem. Soc., 1994, 116,
Please contact Glen Research if you have any questions or comments!